肝疾患組織からの肝幹細胞の分離と分化に関する最近の研究

抄録

Liver transplantation is a standard treatment for serious liver failures and for liver based inborn errors of metabolism. However, shortage of livers is a major limiting factor and alternative solutions are expected in liver therapy. Cell transplantation using normal hepatocytes is awaited with great interest, but is still limited by limited cell proliferation and others. Hepatic stem/progenitor cells are activated in rodent models of liver regeneration after toxic injury. In humans, hepatic stem/progenitor cells may be activated and become enriched in different liver diseases such as chemical, viral hepatitis and cirrhosis. In this review, we describe isolation and differentiation of hepatic stem/ progenitor cells derived from human liver tissues with different liver diseases as a potential candidate for cell treatment in liver diseases.