Organ Biology
Online ISSN : 2188-0204
Print ISSN : 1340-5152
ISSN-L : 1340-5152
Creation of vascularized and functional organ from human iPS cell
Takanori TakebeHideki Taniguchi
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Keywords: iPS cell, liver, organ bud
JOURNAL FREE ACCESS

2013 Volume 20 Issue 2 Pages 182-185

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Abstract

Despite many reports describing functional cell differentiation from pluripotent stem cells (PSCs), for over decades, researchers have failed to generate a complex vascularised organ as an alternative to living/cadaveric organ transplantation. To hurdle this, we focused on the most primitive process of organogenesis. By recapitulating endothelial and mesenchymal interactions during bud development, three-dimensional liver buds(iPSC-LB)were successfully created from iPSCs, resembling in vivo liver buds. Formation of functional vasculatures stimulated the maturation of iPSC-LB into adult liver-like tissues with human specific-functions in vivo. We here propose a new paradigm of(re)generative medicine through the in vitro-derived bud transplant.

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© 2013 The Japan Society for Organ Preservation and Medical Biology
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