心停止後ラット腎臓の functional MRI を用いた詳細な障害の評価と腎移植後グラフト予後予測可能性

貝森 淳哉; 岩井 聡美; 小林 英司; 畑中 雅喜; 津田 秀年; 小尾 義嗣; 奥見 雅由; 矢澤 浩治; 市丸 直嗣; 楽木 宏美; 野々村 祝夫; 猪阪 善隆; 高原 史郎

doi:10.11378/organbio.21.179

Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors

Jun-Ya Kaimori, Satomi Iwai, Eiji Kobayashi, Masaki Hatanaka, Hidetoshi Tsuda, Yoshitsugu Obi, Masayoshi Okumi, Koji Yazawa, Naotsugu Ichimaru, Hiromi Rakugi, Norio Nonomura, Yoshitaka Isaka, Shiro Takahara

Author information

Jun-Ya Kaimori
Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine
Satomi Iwai
Laboratory of Small Animal Surgery I, School of Veterinary Medicine, Kitasato University;
Eiji Kobayashi
Division for Development of Advanced Medical Technology, Jichi Medical University
Masaki Hatanaka
Department of Geriatrics and Nephrology, Osaka University Graduate School of Medicine
Hidetoshi Tsuda
Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine
Yoshitsugu Obi
Department of Geriatrics and Nephrology, Osaka University Graduate School of Medicine
Masayoshi Okumi
Department of Specific Organ Regulation(Urology), Osaka University Graduate School of Medicine
Koji Yazawa
Department of Specific Organ Regulation(Urology), Osaka University Graduate School of Medicine
Naotsugu Ichimaru
Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine
Hiromi Rakugi
Department of Geriatrics and Nephrology, Osaka University Graduate School of Medicine
Norio Nonomura
Department of Specific Organ Regulation(Urology), Osaka University Graduate School of Medicine
Yoshitaka Isaka
Department of Geriatrics and Nephrology, Osaka University Graduate School of Medicine
Shiro Takahara
Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine

Keywords: organ preservation, BOLD MRI, diffusion MRI

JOURNAL FREE ACCESS

2014 Volume 21 Issue 2 Pages 179-181

DOI https://doi.org/10.11378/organbio.21.179

Details

Abstract

We assessed cardiac death(CD)kidney tissue by BOLD(blood oxygenation-level dependency)MRI and diffusion MRI. BOLD and diffusion MRI successfully and non-invasively imaged and quantified red cell congestion and edema in CD grafts respectively. They can predict organ damage, and therefore the outcome, of transplanted CD kidney grafts.

Corresponding author

Register with J-STAGE for free!