膵島移植前Mitomycin-C 処置によるグラフト生着延長効果

抄録

Islet transplantation has recently been shown to be successful in replacing pancreatic endocrine function into recipient with severe type 1 diabetes, but long-term insulin independence is usually not sustainable. We have previously reported that ex vivo Mitomycin-C treatment for islet graft prior to implantation induced a significant prolongation of islet graft survival in allograft and concordant xenograft transplantation model. Based on our experimental findings, prolongation of engraftment by sublethal genotoxic stress from MMC, without immune-suppressive agent, are characterized as 1) inhibition of cell death, 2) immune hyporesponsiveness at implantation site. This review will focus on our fi ndings about ex vivo MMC treatment for islet graft and the prospects based on the latest fi ndings.