Generation of the functional organ by utilizing in vivo developmental environment

Abstract

The field of cell therapy in regenerative medicine has made remarkable progress, and in vitro differentiated cells are about to be used for disease therapy, but it is difficult to generate functional organs with a three-dimensional structure in vitro. On the other hand, the blastocyst complementation is a method of generating an organ in an animal body that is morphologically and functionally identical to an in vivo organ by utilizing the chimera-forming ability of pluripotent stem cells. This article described the current status and future prospects of organ generation using this blastocyst complementation method.