Pre-clinical study of human cell-based vascular graft using a novel operational immunodeficient pig model

Abstract

Stem cell technology and tissue engineering technology have remarkably developed in recent years. Large animal models which are similar to humans in anatomy have been preferred to mice and rats in preclinical studies to evaluate the efficacy and safety of the human call-based regenerative medical products. We successfully developed an operational immunodeficient pig model by surgical procedure combined with conventional immunosuppressive therapy. As a result, the long-term implantation study of human cell-based vascular grafts constructed by using a Bio-3D printer enabled the evaluation of the pre-clinical efficacy. This immunodeficient pig model is expected to be widely used in clinical development of regenerative medical products in the future.