REVIEW OF SIX CASES OF OLFACTORY NEUROBLASTOMA

Abstract

Olfactory neuroblastoma is an uncommon malignancy of the nasoparanasal sinus. We conducted a retrospective review of the clinical and imaging data of cases encountered by us over the past 10 years. There were three male and three female patients, and the main presenting symptoms were nasal congestion and nasal bleeding. Five of the six patients showed locally progressive disease at diagnosis and had a comparatively long duration of symptoms. Cervical lymph node metastasis was detected in three patients. As for the treated cases and pre-and treated cases, all patients remained alive during the observation period. However, one patient who received no treatment died of the disease and one patient was lost to follow-up. Recently, combination chemotherapy as well as conventional surgical therapy and radiotherapy, including proton radiotherapy, have improved the prognosis. However, this malignancy is known to recur often, and two of our patients showed recurrence. Long-term and careful follow-up is necessary for patients with olfactory neuroblastoma.