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Volume 56, Issue Supplement1
Displaying 1-23 of 23 articles from this issue
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[in Japanese]2013 Volume 56 Issue Supplement1 Pages s7
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSDownload PDF (154K) -
Tomofumi Hoshino, Yuki Hirose, Bungo Nishimura, Isao Uemaetomari, Keij ...2013 Volume 56 Issue Supplement1 Pages s8-s12
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe clinical records of outpatients treated at the Department of Otolaryngology, University of Tsukuba Hospital, during the period from January 2002 to December 2011 were reviewed. The outpatient office attendance, total number of outpatients and the number of new outpatients increased by 1.45-fold, 1.24-fold and 1.31-fold, respectively, over the 10-year period. Analysis for the age distribution of the new outpatients indicated a higher mean age of the new outpatients. The gender distribution was almost even (male: female=1.08: 1). The geographic distribution of the referring doctors was analyzed. Most referred patients came from the south and west areas of Ibaraki prefecture, while there were some patients referred from other areas of Ibaraki prefecture or even outside Ibaraki prefecture. The number of otolaryngologists in Ibaraki prefecture is lower than the average for Japan. Furthermore, the distribution of otolaryngologists in Ibaraki prefecture was also revealed to be inhomogeneous. Our department at the University of Tsukuba Hospital is a keystone regional otolaryngology unit in Ibaraki prefecture.View full abstractDownload PDF (516K) -
Yuki Hirose, Keiji Tabuchi, Tetsurou Wada, Akira Hara2013 Volume 56 Issue Supplement1 Pages s13-s19
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe clinical records of inpatients treated at the University of Tsukuba Hospital, the Department of Otolaryngology, from January 2001 to December 2011 were reviewed. The total number of inpatients was 2,956. Neoplastic diseases were the most common, and the number of malignant neoplasms was 1,260 (42.6% of all cases). The affected sites were distributed as follows: pharynx, 22.7%; larynx, 15.5%; tongue and oral cavity, 5.5%; salivary glands, 8.6%; neck, 8.4%; nasal and paranasal sinuses, 14.7%; ear, 22.5%; others, 2.0%.View full abstractDownload PDF (1061K) -
Keiko Oikawa, Mariko Nakamagoe, Keiji Tabuchi, Tetsuro Wada, Akira Har ...2013 Volume 56 Issue Supplement1 Pages s20-s25
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSWe reviewed the data of 57 cases with hearing impairment detected by newborn hearing screening from April 2006 to March 2011. The newborn hearing screening was conducted by automated auditory brainstem response (AABR) in 21 cases, by otoacoustic emission (OAE) in 31 cases, and by a combination of OAE and AABR in 5 cases. The mean age of the infants at the first visit was 2.5 months, and 26 infants were brought within one month after birth. Twenty-five of the 57 infants were referred from the maternity clinic. Newborn hearing screening showed hearing impairment on both sides in 21 cases and hearing impairment on one side in 36 cases. Bilateral hearing loss was observed in 16 cases, including 8 of 10 cases screened by AABR, 6 of 11 cases screened by OAE, and 2 cases who were indicated hearing impairment on one side by OAE. The mean age at the first fitting of a hearing aid was 8.9 months, however, when one case with progressive hearing loss was excluded, it was 6.9 months.View full abstractDownload PDF (586K) -
Tomofumi Hoshino, Keiji Tabuchi, Tetsuro Wada, Akira Hara2013 Volume 56 Issue Supplement1 Pages s26-s30
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSIn patients with middle ear disease suffering from conductive hearing loss who are scheduled for operation, preoperative examination to determine the status of the ossicular chain is important. We conducted two tests in addition to the previously used tests: a liquid test and an acoustic reflex test. From January 2002 to December 2011, we encountered 16 patients in whom the status of the ossicular chain was identified by the operation findings. Ten patients had ossicular discontinuity and 6 patients had ossicular fixation. The accuracy rate of the liquid test was 80% for ossicular discontinuity and 66% for ossicular fixation. Although the acoustic reflex test shows a reversed pattern wave in cases of ossicular chain abnormality, only 4 of 16 patients in our series showed the reversed pattern. The total accuracy rate of the acoustic reflex test for the diagnosis of ossicular abnormality was 75% (3 of 4 patients). Both tests showed a high accuracy and are considered to be useful and effective tests.View full abstractDownload PDF (561K) -
Keiji Tabuchi, Yuki Hirose, Tomofumi Hoshino, Bungo Nishimura, Isao Ue ...2013 Volume 56 Issue Supplement1 Pages s31-s33
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe clinical records of 361 patients (377 ears) with middle ear diseases operated at the University of Tsukuba Hospital from January 2002 to December 2011 were reviewed. The majority of patients (247 ears: 65.5%) were diagnosed as having chronic otitis media with cholesteatoma. The overall success rate of treatment to improve hearing was 63.2% in patients with a cholesteatoma. There was a tendency towards the success rate being higher in patients undergoing type I tympanoplasty.View full abstractDownload PDF (292K) -
Masahiro Nakayama, Tomonori Yoshimura, Kei Ashizawa, Mariko Nakamagoe, ...2013 Volume 56 Issue Supplement1 Pages s34-s39
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSAlthough otogenic intracranial complications are considered to be relatively rare, they may still be potentially life-threatening. We report our experiences with 5 patients presenting with otogenic intracranial complications who were treated at the University of Tsukuba Hospital from 2002 to 2011. Case 1 was a 7-year-old girl who presented with fever, otalgia, and headache, who had been diagnosed as having acute otitis media at another hospital. Magnetic resonance imaging (MRI) demonstrated mastoiditis with sigmoid sinus thrombophlebitis. The child was successfully treated by intravenous antibiotic therapy. Case 2 was a male in his 60's who presented with the complaints of dizziness and vomiting. MRI showed an epidural abscess in the posterior cranial fossa caused by otitis media with a cholesteatoma. Abscess drainage, tympanoplasty and mastoidectomy were performed. Case 3 was a female patient in her 40's with inner ear anomalies associated with recurrent meningitis. During surgical treatment, cerebrospinal fluid leakage through a bony defect in the stapedial footplate was observed. After removal of the stapes, intralabyrinthine obliteration was performed and the oval window was sealed. The two remaining patients were two children with meningitis complicating otitis media with a cholesteatoma. Both cases were successfully treated by surgery.
A clinical suspicion of otogenic intracranial complications would seem to be essential to make an accurate diagnosis during the early stage of the disease and achieve successful outcomes.View full abstractDownload PDF (938K) -
Keiji Tabuchi, Yuki Hirose, Tomofumi Hoshino, Bungo Nishimura, Isao Ue ...2013 Volume 56 Issue Supplement1 Pages s40-s42
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSBone pate (a mixture of bone dust and fibrin glue) was used in 15 patients undergoing cochlear implant surgery for fixation of the lead wire in the region of the posterior tympanotomy and the receiver stimulator at its bed. The postoperative course was uneventful in all patients, and free from problems such as infection of the wound, necrosis of the overlying skin, and migration of the electrode. This finding suggests that use of the bone pate was useful for cochlear implant surgery.View full abstractDownload PDF (276K) -
Tetsuro Wada, Masahiro Nakayama, Yuki Hirose, Mariko Nakamagoe, Bungo ...2013 Volume 56 Issue Supplement1 Pages s43-s48
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe clinical records of 187 patients with vestibular schwannoma (VS) diagnosed at the University of Tsukuba Hospital between 1988 and 2011 were reviewed. There were 11 cases of neurofibromatosis type 2 (NF2). Of these 11 cases with NF2, 10 had bilateral VSs and one had a unilateral VS and multiple meningiomas and schwannomas.
There were 2 cases of unilateral VS who were under the age of 20 years. On the other hand, there were also 2 cases of NF2 over the age of 60 years. The mean age±standard deviation of the patients with unilateral VS and NF2 was 52.9±14.3 and 39.0±18.1, respectively.
Hearing loss was the most common chief complaint among the VS patients. Bilateral hearing loss was revealed in 4 of the 11 patients with NF2 at the first visit. However, 12 of 21 ears with VS among the 11 patients with NF2 had progressed to profound hearing loss by the last follow-up audiometry. Hearing preservation was difficult in most cases of NF2, irrespective of the treatment strategy, which was selected from among (a) wait and scan, (b) tumor resection, and (c) radiotherapy.
The treatment strategies in the patients with unilateral VS depended mainly on the tumor size; those for NF2 also depended on the hearing status. Obtainment of informed consent was extremely important for appropriate decision-making for the treatment of NF2.View full abstractDownload PDF (390K) -
Tomonori Yoshimura, Hirotatsu Ohara, Kei Ashizawa, Masahiro Nakayama, ...2013 Volume 56 Issue Supplement1 Pages s49-s53
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe data of a total of 82 patients with malignancies of the nasal cavity and paranasal sinuses who were initially treated at the University of Tsukuba Hospital between 2002 and 2011 were reviewed. The mean age (±standard deviation) was 63.1 (±14.6) years, and the male-female ratio was 2.73: 1. The tumor originated from the maxiallry sinus in 40 cases (48.8%), from the nasal cavity in 28 cases (34.1%), from the ethmoid sinus in 9 cases (11.0%), and from other sinuses in 5 cases (6.1%).
At our department, treatment for maxillary cancer is initiated with chemoradiotherapy concurrently with intraarterial infusion of fluorouracil, followed by planned surgery for appropriate candidates. The disease-specific 5-year survival rate was 57.0% in our series of patients with maxillary cancer.
Malignancies of the nasal cavity and paranasal sinuses may present with diverse clinical features and further investigation is needed to establish appropriate treatment strategies for individual cases.View full abstractDownload PDF (412K) -
Isao Uemaetomari, Tomonori Yoshimura, Hirotatsu Ohara, Kei Ashizawa, M ...2013 Volume 56 Issue Supplement1 Pages s54-s57
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSEleven cases of malignant melanoma in the head and neck region diagnosed and treated at the University of Tsukuba Hospital over a ten-year period were clinically analyzed. The patients consisted of 4 males and 7 females, ranging in age from 20 to 88 years (mean age, 67 years). The tumor originated from the nasal cavity in seven cases and from the maxillary sinus, nasopharyngeal mucosa, external auditory canal and skin of the head in one case each. Most patients were treated by proton beam therapy alone or in combination with surgery and/or chemotherapy. The disease-specific survival rate was 22.5% at 3 years. With recent reports suggesting the effectiveness of proton beam therapy for malignant melanoma of the head and neck region, a combination of treatment modalities including proton beam therapy might improve the survival rate, however, our cases were limited in number. The standard strategy for the treatment of malignant melanoma of the head and neck region should be established, including proton beam therapy.View full abstractDownload PDF (348K) -
Mariko Nakamagoe, Keiko Oikawa, Kei Ashizawa, Masahiro Nakayama, Bungo ...2013 Volume 56 Issue Supplement1 Pages s58-s63
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSOlfactory neuroblastoma is an uncommon malignancy of the nasoparanasal sinus. We conducted a retrospective review of the clinical and imaging data of cases encountered by us over the past 10 years. There were three male and three female patients, and the main presenting symptoms were nasal congestion and nasal bleeding. Five of the six patients showed locally progressive disease at diagnosis and had a comparatively long duration of symptoms. Cervical lymph node metastasis was detected in three patients. As for the treated cases and pre-and treated cases, all patients remained alive during the observation period. However, one patient who received no treatment died of the disease and one patient was lost to follow-up. Recently, combination chemotherapy as well as conventional surgical therapy and radiotherapy, including proton radiotherapy, have improved the prognosis. However, this malignancy is known to recur often, and two of our patients showed recurrence. Long-term and careful follow-up is necessary for patients with olfactory neuroblastoma.View full abstractDownload PDF (569K) -
Hidekazu Murashita, Keiji Tabuchi, Tomofumi Hoshino, Isao Uemaetomari, ...2013 Volume 56 Issue Supplement1 Pages s64-s68
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSEndoscopic endonasal transsphenoidal surgery has been performed owing to its advantages, such as its less invasive nature and possibility of more aggressive tumor removal of extrasellar lesions. In 2010, we began performing transnasal endoscopic skull base surgery without using the operating microscope. Here, we describe the surgical approach of skull base surgery at our institute.
For tumors located on the tuberculum sellae, we remove the lower two-thirds of the superior turbinate and perform posterior ethmoidectomy. Drilling of the tuberculum sellae bone and sella is then performed. For preventing olfactory dysfunction, the drilling area was minimized, and the upper one-third of the superior turbinate is preserved as much as possible.
For tumors showing lateral extension towards the course of the internal carotid artery, we select the transmaxillary-transpterygoidal approach. This approach provided surgical access to the cavernous sinus and petrous bone. For protecting the sinus function, we do not remove the vertical portion of the middle turbinate. The vidian nerve is preserved to prevent a dry eye.
Endoscopic skull base surgery with the aid of nasal and skull base techniques has enabled more aggressive removal of extrasellar tumors. We propose that it is necessary for otolaryngologists to conduct this operation strictly in collaboration with neurosurgeons.View full abstractDownload PDF (838K) -
Bungo Nishimura, Tomonori Yoshimura, Kei Ashizawa, Masahiro Nakaya ...2013 Volume 56 Issue Supplement1 Pages s69-s72
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSWe report on patients with small cell carcinoma of the head and neck encountered at the University of Tsukuba Hospital from 1994 to 2011. There were eight patients, including six men and two women, and the average age was 63 years (32～81 years old). The primary site of the carcinoma was the nasal cavity in two patients, maxillary sinus in one patient, ethmoidal sinus in one patient, the nasopharynx in one patient, the larynx in two patients, and the parotid gland in one patient. Among the eight patients, six had advanced, stage IV cancer, and two (one with cancer arising from the nasal cavity and one with cancer of the larynx) had stage II disease (T2N0M0). Immunohistochemistry was useful for the diagnosis. The main treatment modality employed was radiotherapy plus chemotherapy with CDDP and VP16, which is used for lung small cell carcinoma, while two patients were treated by surgery. Four patients died of the primary disease in eight to 49 months, one patient died of other disease in two months, and one patient remained alive with carcinoma for 4 months. Two patients, one with the tumor of the larynx and the other with the tumor arising from the nasal cavity, showed disease-free survival for 64 months and 66 months, respectively.
Eventually all of the patients died of the primary disease accompanied by distant metastases. Early detection, early diagnosis and early treatment are essential for improving the prognosis, and establishment of a more effective therapeutic protocol is desired.View full abstractDownload PDF (326K) -
Kei Ashizawa, Tomonori Yoshimura, Hirotatsu Ohara, Masahiro Nakaya ...2013 Volume 56 Issue Supplement1 Pages s73-s79
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSData of a total of 62 patients with oral carcinoma treated at the University of Tsukuba Hospital between January 2001 and December 2010 were reviewed. Out of the 62 patients, in 59, the tumors were histopathologically diagnosed as squamous cell carcinoma (SCC), and the remaining three as verrucous carcinoma. Treatment for each patient was determined according to the TNM classification (UICC, 1997) and the histopathological features. The three patients with verrucous carcinoma in whom the tumors were insensitive to radiation or chemotherapy were treated surgically. For stage I or II SCC cases, except for tongue cancer, full-dose irradiation was the treatment of choice. For cases of stage I or II tongue cancer, brachytherapy (RALS) or surgery was the treatment of choice. In stage III or IV cases, the treatment of choice was a combination of surgery, radiotherapy and chemotherapy. The 5-year survival rate of the SCC cases, overall, was 62.6% as analyzed by the Kaplan-Meier method, while the rates for the stage I, II, III, and IV cases were 100%, 75.6%, 37.5%, and 40.7%, respectively.View full abstractDownload PDF (586K) -
Kei Ashizawa, Tomonori Yoshimura, Hirotatsu Ohara, Masahiro Nakaya ...2013 Volume 56 Issue Supplement1 Pages s80-s85
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSData of a total of 35 patients with nasopharyngeal carcinoma treated at the University of Tsukuba Hospital between 2001 and 2011 were reviewed. All of the cases, except 3, were classified according to the WHO histological classification; the 3 exceptions consisted of 2 cases of adenoid cystic carcinoma and 1 of small cell carcinoma. According to the TNM classification (UICC, 2009), the clinical stage was I in 1 case, II in 7 cases, III in 18 cases, and IV in 9 cases. Concurrent chemoradiotherapy was the fundamental treatment modality employed. A total of 3 courses of chemotherapy were scheduled to be administered during the radiotherapy. The chemotherapeutic regimen consisted of 5-fluorouracil® and cisplatin. Lymph node dissection was performed in the two patients with metastatic cervical lymph nodes in whom the nodes were too large to control by this treatment. Recurrence after complete response was noted in 3 cases, who were then rehospitalized and administered salvage medical and/or surgical treatment. As a consequence, the 5-year disease specific survival rate was 68.2%.View full abstractDownload PDF (643K) -
―CHEMORADIOSELECTION BY TAR THERAPY―Tetsuro Wada, Tomonori Yoshimura, Hirotatsu Ohara, Kei Ashizawa, Masah ...2013 Volume 56 Issue Supplement1 Pages s86-s91
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSThe data of 91 patients with oropharyngeal carcinoma treated at the University of Tsukuba Hospital between 2002 and 2011 were reviewed. The mean age (±standard deviation) was 62.5 (±10.2) years and the male-female ratio was 5.5: 1. The tumor originated from the lateral wall in 58 cases (63.7%), the anterior wall in 22 cases (24.2%), the superior wall in 8 cases (8.8%), and the posterior wall in 3 cases (3.3%). Six cases were revealed to be positive for human papilloma virus (HPV) among the 7 cases examined. Only supportive care was administered in 12 cases. The remaining 79 cases were treated, and the disease-specific 5-year survival rate was 55.6%. Smoking and alcohol consumption were significantly related to the disease-specific survival rate.
At our department, chemoradiotherapy is initiated with 45 Gy of radiation concurrently with a novel oral fluoropyrimidine derivative (Teysuno®, Taiho Phamaceutical Co., Ltd.) and vitamin A (TAR therapy), to improve the rate of curative surgical resection and select appropriate candidates for further definitive chemoradiotherapy to allow organ preservation (chemoradioselection). Chemoselection by induction chemotherapy, or chemoradioselection by initial concurrent chemoradiotherapy is considered to be important to make individualized treatment selection for patients with oropharyngeal carcinoma, because of the highly variable response to definitive chemoradiotherapy among cases.View full abstractDownload PDF (407K) -
Bungo Nishimura, Tomonori Yoshimura, Kei Ashizawa, Masahiro Nakayama, ...2013 Volume 56 Issue Supplement1 Pages s92-s96
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA total of 84 patients with hypopharyngeal malignant tumors were treated at the University of Tsukuba Hospital between 2002 and 2011. In all patients, the tumors were histopathologically diagnosed as squamous cell carcinoma. The mean age was 66.0 years and the male-female ratio was 9.6: 1. The primary lesions were in the piriform sinus in 83.3%, the posterior wall in 9.5% and the postcricoid area in 7.2% of the cases. The majority (87.0%) of the patients had advanced cancer (stage III or IV), and the main treatment modality used was concurrent chemoradiotherapy. Total pharyngolaryngectomy was performed in 19 cases. The disease-specific 5-year survival rate was 53.8%. The 5-year survival rate in the group that was treated by total pharyngo-laryngectomy was 76.5%, much better than that in the entire subject population of hypopharyngeal cancer. Therefore, surgery appears to be important to improve the prognosis of this disease.View full abstractDownload PDF (610K) -
Masahiro Nakayama, Tomonori Yoshimura, Kei Ashizawa, Mariko Nakamagoe, ...2013 Volume 56 Issue Supplement1 Pages s97-s103
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA clinical study was conducted of 180 patients, including 159 men and 21 women, with laryngeal malignant tumors who were treated at the Department of Otolaryngology at the Tsukuba University Hospital between January 2002 and December 2011. The mean age of the patients was 69.0 years and the male-female ratio was 7.3: 1. Of the 180 patients, 134 (74.4%) had glottic cancer, 40 (22.2%) had supraglottic cancer, and 6 (3.3%) had subglottic cancer. Of the patients with glottic cancer, 68 (51.1%) had stage I disease, 30 (22.2%) had stage II disease, 23 (17.0%) had stage III disease, and 13 (9.6%) had stage IV cancer. Of the patients with supraglottic cancer, 6 (15.0%) had stage I disease, 4 (10.0%) had stage II disease, 7 (22.5%) had stage III disease, and 23 (52.5%) had stage IV disease. Of the patients with subglottic cancer, 4 (66.7%) had stage II disease, 1 (16.7%) had stage III disease, and 1 (16.7%) had stage IV disease. The 5-year survival rates of patients with stage I, II, III and IV disease were 96.5%, 78.8%, 66.7% and 52.7%, respectively. The 5-year survival rates of the patients with glottic and supraglottic cancer were 89.8% and 54.0%, respectively. The overall 5-year survival rate was 81.9%. The percentage of laryngeal preservation in the patients was 64.4%. Further analysis revealed that the percentages of laryngeal preservation were 73.9%, 47.5% and 33.3% in the patients with glottic, supraglottic and subglottic cancers, respectively. According to this result, it was possible to preserve the larynx in some cases of even T3 or T4 laryngeal carcinoma. On the other hand, local recurrence occurred in 7 cases of T1 glottic cancer who received radiotherapy alone. Therefore, careful long-term observation of these patients is necessary.View full abstractDownload PDF (552K) -
Isao Uemaetomari, Tomonori Yoshimura, Hirotatsu Ohara, Kei Ashizawa, M ...2013 Volume 56 Issue Supplement1 Pages s104-s107
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA clinical analysis was conducted of seven alaryngeal patients who had undergone tracheo-esophageal puncture (TEP) with Provox® 2 over a 2-year period. The patients consisted of 6 males and 1 female, ranging in age from 49 to 83 years old (mean age, 61 years). The underlying diseases were laryngeal carcinoma in 2 cases and hypopharyngeal carcinoma in 5 cases. All the TEP procedures were performed as secondary operations under general anesthesia. The average operation time was 20 minutes (range, 7 to 43 minutes). QOL analysis was also performed using the revised edition of the Japanese Voice Handicap Index (VHI).View full abstractDownload PDF (334K) -
Yuki Hirose, Tadamichi Tobita, Keiji Tabuchi, Tetsurou Wada, Akira Har ...2013 Volume 56 Issue Supplement1 Pages s108-s112
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA retrospective investigation was performed in 174 patients with major salivary gland tumors who had undergone surgery at our department between 2002 and 2011. The patients consisted of 143 with parotid gland tumors, 30 with submandibular gland tumors, and 1 with a sublingual gland tumor. The percentage of malignant tumors among the submandibular gland tumors was 36.7%, which was higher than that among the parotid gland tumors (21.0%). Fine needle aspiration cytology (FNAC) was the most commonly used modality for the preoperative diagnosis of malignancy. In this series, the sensitivity, specificity, and accuracy of FNAC for the detection of malignant tumors were 90.6%, 93.5%, and 92.8%, respectively. Retrospectively, the accuracy of FNAC for diagnosis of the histologic tumor type was 64.0%. Those results suggest that ultrasound-guided FNAC is useful for preoperative diagnosis of salivary gland tumors.View full abstractDownload PDF (603K) -
Masahiro Nakayama, Tomonori Yoshimura, Kei Ashizawa, Mariko Nakamagoe, ...2013 Volume 56 Issue Supplement1 Pages s113-s117
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA total of 38 patients with thyroid tumors were treated at the University of Tsukuba Hospital between 2002 and 2011. The patients consisted of 11 patients with benign tumors, and 27 with malignant tumors. Histopathologically, the tumors were diagnosed as adenomatous nodule, papillary adenocarcinoma, poorly differentiated carcinoma, and undifferentiated carcinoma in 11, 24, 2, and 1 of the patients, respectively. A hemithyroidectomy with isthmectomy was performed in all the patients with benign tumors. For the 27 patients with malignant tumors, a hemithyroidectomy with isthmectomy was performed in 55.6%, a subtotal thyroidectomy in 7.4%, and a total thyroidectomy in 37% of cases. Neck dissection including D1 was performed in all patients with thyroid cancer. D1 neck dissection was performed in 44.4%, D2a neck dissection in 40.7%, and D3a neck dissection in 14.8% of all the cases. Recurrence occurred in 6 of the 27 patients with malignant tumors. One of these 6 cases was the patient with undifferentiated carcinoma, who died within 12 months of the initial diagnosis.View full abstractDownload PDF (353K) -
Hideki Okubo, Masahiro Nakayama, Yuki Hirose, Shuho Tanaka, Bungo Nish ...2013 Volume 56 Issue Supplement1 Pages s118-s122
Published: March 05, 2013
Released on J-STAGE: March 05, 2014
JOURNAL FREE ACCESSA total of 61 patients with head and neck cancer received proton beam radiotherapy at the University of Tsukuba hospital between January 2002 and December 2011. The patients included 22 with sinonasal cancer, 12 with nasopharyngeal carcinoma, 11 with mesopharyngeal carcinoma, and 16 with other sites.
Of the total number of tumors treated, 52 were judged as showing complete or partial response, and the overall 5-year survival rate of the patients was 70.6%; furthermore, the 5-year survival rate was 64.4% in cases of sinonasal cancer and 87.5% in cases of nasopharyngeal carcinoma. Brain necrosis was observed in 2 patients with intracranial tumor invasion.
Proton beam therapy is effective for the treatment of head and neck cancer, especially for that of nasopharyngeal and sinonasal cancer. Further study will be needed for evaluation of the safety and efficacy of proton therapy for the treatment of other types of head and neck cancer.View full abstractDownload PDF (672K)
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