Abstract
The histopathological nature of rhinopathia gangrenosa progressiva is not clear. One form of this disease, classical malignant granuloma, showed a comparatively circumscribed progression. This case was a 14-year-old girl who underwent surgery for extripation of a retroperitoneal tumor. The tissue of this tumor showed malignant cells with strong inflammatory reaction. This suggested that histopathological findings were compatible with rhinopathia gangrenosa progressiva. At this point, the patient recieved an otorhinolaryngological examination for the first time. The right nasal cavity was filled with a hemorrhagic granuloma which was gray in color, it showed a strong tendency to be necrotic with an irregular surface. A biopsy specimen of the nasal lesion was diagnosed as a Stewart-type granuloma that clearly presented the characteristics of a typical classical malignant granuloma. In addition, this lesion had the same features as a retroperitoneal lesion.
Alleviation was achieved by application of the BH-AC VP-VPL therapeutic regimen, and the patient in presently showing a favorable course.
