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Volume 37, Issue 1
Displaying 1-16 of 16 articles from this issue
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[in Japanese]1994 Volume 37 Issue 1 Pages 6-21
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
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Kazuhisa Kitagawa1994 Volume 37 Issue 1 Pages 22-40
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe neurogenesis and aging of the olfactory epithelium in rat were investigated with immunohistochemical and electron microscopic methods. The rats used in this study were embryonic day 19, postnatal day 3, adult, and aged rats. Anti-N-CAM (neural cell adhesion molecule), anti-MAP 5 (microtubule associated protein 5) and anti-MAP 2 antibodies were used for immunohistochemical method. In the adult rats, N-CAM and MAP 5 immuno-positive stainings were exclusively found in the basal and middle layer of the epithelium and the axons in the lamina propria. Immunoreactivity to anti-MAP 2 was found throughout the olfactory cell layer of the epithelium. In the embryonic and neonatal rat, the positive stainings of anti-MAP 5 were located in the olfactory cell layer of the epithelium, occupying a position closer to the epithelial surface. In the neonatal rats, the cells which differentiated in the embryonic period immigrate towards the free surface. The grade of the maturation of MAP 5-positive cells is thought to be not high. I consider that the cells in the basal and middle layers were less developed than the MAP 5-positive cells, although the morphological structure appeared almost fully developed. MAP 2 was only detectable near the free surface of the epithelium. From their flask-like shape, these cells might be the so-called “microvillar cell”.
In the aged rats, the immunoreactivity to anti-MAP 2 was similar to the adult rats. Thus, I speculate that aged rats may have maintained their olfactory acuities. However, on the electron microscopic observation, the thickening of the basement membrane and the decrease in the number of olfactory cells were observed, indicating an age-related change. Furthermore, in the epithelium, the immunoreactivity to anti-NCAM was weak. Therefore, it is thought that the supply of new neurons is not as plentiful as in the younger rats.View full abstractDownload PDF (32460K) -
Osamu Nohara, Takafumi Sugita, Masanori Shiwa, Narihiko Hayashi, Ryuut ...1994 Volume 37 Issue 1 Pages 41-51
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe have performed sinus surgery on cases of severe pediatric sinusitis. In this study, we focused on the pathological findings, especially the location of mucosal inflammation.
There were 18 children in the younger 5 to 9 year old group and 22 children in the older 10 to 15 year old group. Tissues were obtained from 55 sides in the 40 cases. Tissues were taken from the area of the uncinate process, ethmoidal bulla, anterior ethmoid sinus, the basal lamella of the middle turbinate, posterior ethmoid sinus, papyr aceous plate, nasal fontanel and the posterior wall of the maxillary sinus.
The histopathological findings of mucosa at the various sites were divided into those of mucosal epithelium and lamina propria. These findings were classified into three grades for each item, depending on the severity of the changes. The chi-squared test for independent multiple group was used to determine the significance of the differences between the findings at the individual sites.
The follwing findings were obtained;
1) Severe inflammation was observed at the nasal fontanel according to the higher incidence of epithelium hypertrophy, chronic inflammatory cell infiltration and fibrination in the lamina propria.
2) The younger children showed no differences in chronic inflammation at the individual sites in the nose while a lower incidence was observed at the posterior ethmoid sinus in the older children. Thus, along with growth, it seems that the disease proceeds from a diffuse sinusitis to a localized sinusitis.
3) The younger children showed more severe fibrination in the lamina propria than the older children. This finding indicates that a cure would be more difficult to achieve in the younger children with conservative treatment.View full abstractDownload PDF (1142K) -
Shigeyuki Murono, Tetsuya Takiguchi, Ikuo Nagayama1994 Volume 37 Issue 1 Pages 52-56
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSForty-eight patients with parotid tumors treated in the Department of Otolaryngology, Kanazawa University Hospital during the four and a half years period between January 1988 and June 1992 were reviewed. Thirty-seven cases were benign tumors while eleven were malignant. In benign tumors, twenty-four cases were pleomorphic adenoma, eleven cases were Warthin's tumor. In malignant tumors, six cases were adenoidcystic carcinoma. Most of the parotid tumors were epithelial tumor and non-epithelial tumors were rare. We encounterd 49-year-old female with a parotid lipoma, which is rare among parotid non-epithelial tumors. She had left parotid tumor, but not facial palsy. The CT scan demonstrated a well-circumscribed low density mass in the left parotid gland, and the CT number of this mass was-99 to-107 HU, as was compatible with lipoma. Under general anesthesia, the patient was operated on. This case showed an effectiveness of the CT scan in the diagnosis of the lipoma.View full abstractDownload PDF (7016K) -
Atsushi Kawasaki, Takanobu Kunihiro, Takahiro Inoue, Masahiro Takahash ...1994 Volume 37 Issue 1 Pages 57-61
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSLipoma that develops symmetrically and diffusely around the neck is called multiple symmetric lipomatosis. Our present case involved heavy drinking, liver disfunction and thrombocytopenia. Drinking excessively, liver disfunction and anemia are seen commonly in this disease, but thrombocytopenia is seen rarely.
We removed lipoma around the neck in one stage, but after 3 months, we saw a recurrence. The count of thorombocyte did not change before and after operation.
We could not understand why thrombocytopenia was seen in this case.View full abstractDownload PDF (6204K) -
SPINOCEREBELLAR DEGENERATIONHiroyuki Ito, Akiji Hanihara, Naoji Amano, Kouichi Hosaka, [in Japanes ...1994 Volume 37 Issue 1 Pages 62-68
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA case of spino-cerebellar degeneration (SCD) was bacteriologicaly studied on the respiratory management. She was a 60-year-old female who was diagnosed as olivo-pont-cerebellar atrophy in 1982. She was tracheostomized on Feburary 25th 1988 because of pneumonia. But she had aspiration pneumonia and admitted on May 18th, 1989. She had aspiration pneumonia so frequently that laryngectomy was recommended, but her family rejected. Antibiotics were used frequently when the pneumonia was deteriorated. She died on January 3rd 1992 due to sudden depression of blood pressure which did not respond to any treatment. The bacteriologic study of her phlegm proved pseudomonus aerugiosa (PA) and staphylococcus aureus (SA). Though antibiotics were used frequently, the resistance of PA against antibiotics such as piperacillin, cefoperazone, gentamicin and amikacin was not changed. But the resistance against fosmicin was increased. SA had come to obtain higher resistance against amikacin, minocyclin and ofloxacin.
In our hospital seven cases of SCD were tracheostomized. In six of them culture study of their phlegm, was performed which proved PA in three, normal flora in two. One of them was negative.
Conclusions: It was suggested that SA had a possibility to change into MRSA in a later period of OPCA which reccurently had pneumonia.
In the final stage of OPCA a surgical procedure may be indicated to prevent respiratory infections with MRSA, which includes laryngectomy, laryngeal closure or separation of the larynx from trachea.View full abstractDownload PDF (798K) -
Yoshihiro Asai, Kazuo Umemura, Michihiko Nozue, Akio Yasuhara, Atsuro ...1994 Volume 37 Issue 1 Pages 69-74
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSubjective disability in activities of daily living was statistically investigated on the 83 patients with vertigo (25 males, 58 females, mean age: 60.8 years old), based on the longitudinal study with mean follow-up period of 2.8 months. These patients were treated mainly with oral medication. Vestibular symptons improved significantly in the two groups with vertigo of peripheral origin and of central origin. In the group of peripheral disorder, subjective disability especially in a quick turn during walking and a head positioning improved most significantly. But no significant improvement was observed in the group of central origin. In conclusion, an investigation by means of a self-rating questionnaire was considered to be useful for evaluating chronological changes of disability of the patients with vertigo of peripheral origin in activities of daily living. On the other hand, a more effective therapeutics or another method for evaluation of therapeutic effectiveness should be explored with regard to subjective disability of daily living of the patients with vertigo of central orlgln.View full abstractDownload PDF (601K) -
Shinya Ohashi, Maki Kitamura, Eiji Hakuhisa, Ryouji Tokasiki, Masaji L ...1994 Volume 37 Issue 1 Pages 75-81
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe histopathological nature of rhinopathia gangrenosa progressiva is not clear. One form of this disease, classical malignant granuloma, showed a comparatively circumscribed progression. This case was a 14-year-old girl who underwent surgery for extripation of a retroperitoneal tumor. The tissue of this tumor showed malignant cells with strong inflammatory reaction. This suggested that histopathological findings were compatible with rhinopathia gangrenosa progressiva. At this point, the patient recieved an otorhinolaryngological examination for the first time. The right nasal cavity was filled with a hemorrhagic granuloma which was gray in color, it showed a strong tendency to be necrotic with an irregular surface. A biopsy specimen of the nasal lesion was diagnosed as a Stewart-type granuloma that clearly presented the characteristics of a typical classical malignant granuloma. In addition, this lesion had the same features as a retroperitoneal lesion.
Alleviation was achieved by application of the BH-AC VP-VPL therapeutic regimen, and the patient in presently showing a favorable course.View full abstractDownload PDF (9027K) -
Yasuyuki Kimura, Takeo Donjo, Toshiaki Tsukatani, Makoto Sakumoto, Tak ...1994 Volume 37 Issue 1 Pages 82-87
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFour cases of olfactory disorder caused by short exposures to organic solvents are reported. Case 1 was exposed to 1, 1, 1-trichloroethane, and Case 2, 3, 4 to mixture vapor of isopropyl alcohol, xylene, n-hexane and toluene.All cases initially complained of nasal pain, but the symptom disappeared by the first visit for us except one case.X-ray and endoscopic examinations revealed no abnormalities in the olfactory clefts. T & T olfactory acuity test indicated hyposmia in all cases.It is considered that the patients were affected olfactory nerve function including the olfactory receptor site, because of the highly effective fat-solvent properties of organic solvents. Three of the four cases could not make a complete recovery.View full abstractDownload PDF (756K) -
Takahiro Inouye, Tatsuro Ohira, Tatsuhiko Harada, Atsushi Kawasaki, [i ...1994 Volume 37 Issue 1 Pages 88-94
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe report a case of anaplastic carcinoma of the thyroid gland, which is one of the most malignant forms pathologically and clinically.A 41-year-old male visited our department complaining of swelling of his entire neck.MRI revealed a tumor invading the entire neck and a very stenotic trachea though he felt no dyspnea. A biopsy was performed immediately.Pathological diagnosis was spindle cell carcinoma of the thyroid gland with no well-differentiated carcinoma of the thyroid seen.
Although radiotherapy was ineffective, combined chemotherapy (CBDCA 500mg, THPADM 30mg) was considered to be slightly useful. The combined chemotherapy was thus continued until his death but neither distant metastasis nor severe complications were seen.Therefore, we believe that the combined chemotherapy probably have prevented such metastasis to other areas.
Paralysis of the left hypoglossal nerve and facial nerve began 6 months after his first visit. These paralyses were caused by direct invasion of the carcinoma.The patient died one and a half month after these paralyses appeared.View full abstractDownload PDF (12640K) -
Masanori Ishii, Toshinobu Yashiro, Takeshi Kobayashi, Kensaku Kaneta, ...1994 Volume 37 Issue 1 Pages 95-100
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAir sickness can be a serious problem for aircraft crews under training.It is an important problem which must be solved not only for the crews themselves but also from the standpoint of aerial navigation safety.To solve this problem, air forces of various countries desensitize trainees by exposing them to Coriolis acceleration and biofeedback therapy, and they report a curing rate (rehabilitation rate) of 70-84%. However, because these methods require special devices and arduous acceleration training, a programwas developed that is designed to overcome air sickness having the trainee perform certain activities during daily life.This program mainly employs physical stretching exercises, swimming, experience of changes in acceleration, etc.;at the same time, drugs with actions of controlling the autonomic nerve function and antihistaminergic agents are also used if deemed necessary.During the five-year period from 1987 to 1992, eleven aircraft crews were trained using this program to treat air sickness.A rehabilitation rate of 81.8% was obtained.Thus, this program was concluded to be an effective approach to treatment of air sickness.View full abstractDownload PDF (776K) -
Kazuyasu Asai, Mamoru Okihisa, Tatsuya Kitamura, Tomoaki Yonemoto, Har ...1994 Volume 37 Issue 1 Pages 101-106
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSeven Patients (6 males, 1 female), who had undergone endonasal endoscopic reconstruction for fracture of the medial orbital wall, were studied. The fractures were right-sided in 4 and left-sided in 3 patients. CT and the findings during operation showed that the fracture site was confined to the region posterior to the third ground lamella in 3 patients while the site was posterior and anterior to that in 4 patients. In the former cases, diplopia was relatively mild. Other subjective symptoms such as eye pain and headache disappeared immediately after operation. The results suggest the importance and the usefulness of this surgery in avoiding technical problems in late treatment with complications in the paranasal sinuses.View full abstractDownload PDF (6226K) -
[in Japanese]1994 Volume 37 Issue 1 Pages 107-109
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (367K) -
[in Japanese]1994 Volume 37 Issue 1 Pages 110-114
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (582K) -
[in Japanese]1994 Volume 37 Issue 1 Pages 115-120
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
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[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1994 Volume 37 Issue 1 Pages 121-133
Published: February 15, 1994
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESS
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