Abstract
In an attempt of prevent postoperative bleeding and local infection, we prepared a gauze tampon by soaking it with white vaseline combined with dibekacin sulfate to be used at the end of nasal and paranasal surgery.The present study was conducted to evaluate possible analgesic effect of the gauze tampon impregnated with vaseline containing antimicrobial agent plus ufenamate, a nonsteroid anti-inflammatory agent, on insertion and evulsion in comparison with conventional gauze tampon preparations. Analgesic effect was evaluated according to the following two parameters: frequency of the patient's request for the analgesic agent after such procedures as radical paranasal surgery, endonasal sinus surgery and septoplasty, and difference in the severity of pain felt by the patient wearing the tampon on its evulsion. For the latter parameter, in the patient who underwent septoplasty, a tampon containing ufenamate was used on either side as a rule. Efficacy of some extent was observed at relief from pain in the patient on insertion of the tampon after paranasal radical surgery and on evulsion after septoplasty.Analgesic effect on insertion of the tampon after endonasal sinus surgery and septoplasty was not always satisfactory. An adequate effect can be expected to be produced by increasing the content of ufenamate. It was determined that the decrease in the assumed amount of dibekacin sulfate to be emitted from gauze tampon owing to increased ufenamate can be improved by adding surfactant before applying a mixture prepared with dibekacin sulfate ointment and ufenamte ointment and which consists of different bases to gauze, or by changing the tampon material from the currently used cotton to materials such as cellulose acetate.Ufenamate can be rather easily added to and combined with another base, and it is also pharmacologically very stable.If the abovementioned improvement can be attained, we can expect an analgesic effect without losing any antimicrobial effect, and thus achieve an increased utility value.
