SERUM LEVELS OF CYTOKINES BEFORE AND AFTER ADMINISTRTION OF ANTI-ALLERGIC DRUGS

Abstract

Before and after administration of azelastine hydrochloride (Azelastine) in 10 patients with perenial allergic rhinitis, serum levels of cytokines, eg IL-3, IL-4, IL-6, GM-CSF, IFN-γ were measured by enzyme-linked immunosorbant assay. After treatment with Azelastine, the serum levels of IL-6 significantly decreased in three patients disappering every allergic symptoms.
These results suggest that the decrease of IL-6 in the serum may be one of parameters to valuate the effectiveness of Azelastine therapy for patients with allergic rhinitis.