Abstract
To evaluate the relation between the clinical effects and the duration of long-term administration of PXM, 49 patients with chronic sinusitis were treated with RXM, 300 mg/day for the first two weeks followed 150 mg/day, for 6 months at least and 4 years at most, averaged 13 months.
The radiological and symptomatic evaluations were carried out at 10 weeks, 6 months after the initial administration and at the time subjective symptoms were disappeared.
The clinical effect was observed in approximately 60% of the patients at 6 months and at the time subjective symptoms were disappeared, and there was no statistical difference of the effect between these administration periods.
From the results, it was concluded that the longterm administration of RXM should not be continued more than 6 months, and the modality of treatment must be altered to the other than administration of RXM.
