Abstract
The distribution of the drug substance in the nasal cavity and spill of the suspension were studied using Mometasone Furoate Nasal Spray (MF) and Fluticasone Propionate Nasal Spray (FP). The distribution of the drug substance in the nasal cavity was almost same with MF and FP in both normal and allergy models. The total distribution volume after one burst of MF and FP was almost the same.
In the normal model, there was a greater distribution in the anterior nasal cavity with MF, while FP tended to be distributed in the posterior nasal cavity. In the allergy model, there was interference in the distribution of both drugs to some points because of edema, but the distribution of both drugs to the anterior nasal cavity, the main site of nasal allergy, was confirmed.
The distribution in the nasal cavity after a 90°position change with one burst of MF and FP was almost the same as with the levels in normal position. The spill of suspension from nasal cavity after MF administration was significantly less than that after FP as a consequence of the smaller total volume in the case of MF.
