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Volume 40, Issue Supplement3
Displaying 1-7 of 7 articles from this issue
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Yoshinobu Sato, Hiroshi Kurahashi, Kiyomi Tatsumi, Hiromi Wakamatsu, E ...1997 Volume 40 Issue Supplement3 Pages 171-176
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSThe distribution of the drug substance in the nasal cavity and spill of the suspension were studied using Mometasone Furoate Nasal Spray (MF) and Fluticasone Propionate Nasal Spray (FP). The distribution of the drug substance in the nasal cavity was almost same with MF and FP in both normal and allergy models. The total distribution volume after one burst of MF and FP was almost the same.
In the normal model, there was a greater distribution in the anterior nasal cavity with MF, while FP tended to be distributed in the posterior nasal cavity. In the allergy model, there was interference in the distribution of both drugs to some points because of edema, but the distribution of both drugs to the anterior nasal cavity, the main site of nasal allergy, was confirmed.
The distribution in the nasal cavity after a 90°position change with one burst of MF and FP was almost the same as with the levels in normal position. The spill of suspension from nasal cavity after MF administration was significantly less than that after FP as a consequence of the smaller total volume in the case of MF.View full abstractDownload PDF (687K) -
Yoichi Ishizuka, Yukako Imamura, Kunio Terashima, Satoru Koyama1997 Volume 40 Issue Supplement3 Pages 177-181
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSSNP-1, a nasal inhalation capsule containing eucalyptus essence and levogyral menthol, was used to see whether it improves snoring or not.
The subjects were 30 patients with snoring, consisting of 20 males and 10 females, and their mean age was 46.1 years.
The improvement was excellent in 2 patients, fair in 7 patients, moderate in 10 patients and poor in 11 patients.
None of these patients had any side effects of the drug.
SNP-1 can be considered to be an appropriate drug for moderate and mild snoring patients as conservative treatment.View full abstractDownload PDF (957K) -
Nobuo Usui, Toshio Ogoshi, Takafumi Yuasa, Yukiko Yoshino1997 Volume 40 Issue Supplement3 Pages 182-189
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSThe methacholine aerosol provocation test through the nose by Astograph acts as mild irritation for the nasal mucosa. Therefore, this test is considered to have examined the original state of the reaction of the nasal mucosa. However, it is thought that the dose-response curve applies to both the upper and lower airways, as methacholine aerosol is inhaled into the lower airway. Accordingly, the evaluation of the reaction of the nasal mucosa alone must be divided into the upper and lower airways.
We examined three methods : the subtraction method, the L & P method, and the standard method. In the subtraction method, a value indicating respiratory resistance through the mouth is subtracted from a value indicating respiratory resistance through the nose. The L & P method provides a value calculated based on the equation created by Lacourt and Polger. The standard method provides a value indicating anterior rhinomanometry.
Conclusions : 1) The subtraction method was found to have the highest sensitivity of all methods tested for the methacholine aerosol provocation test through the nose, but this method was not able to completely eliminate the influence of the lower airway. 2) The L & P method can be used to divide the upper and lower airways, but this method needed a complicated count and was found to be less sensitive than the other two methods. 3) The standard method requires an additional rhinomanometer unit. However, the sensitivity of this method for the provocation test was found to be good. This method was considered most suitable for the evaluation of the reaction of the nasal mucosa alone.View full abstractDownload PDF (1050K) -
FOCUS ON THE SIDE PHENOMENAKenji Suzuki, Shunkichi Baba1997 Volume 40 Issue Supplement3 Pages 190-194
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSWe examined bacteria from the nasal cavities in 93 outpatients with relatively mild cases of paranasal sinusitis before and after 8 weeks of nasal nebulization with antibacterial agents performed 3 times a week.
The bacterial eradication rate was 28.0%. We observed that 42% of patients showed no bacterial change (4% with MIC increasing) and 30% showed superinfection (mainly with normal flora and 8% with resistant bacteria and fungi), among 50 patients who demonstrated bacteria before the start of this trial. We also observed post-trial bacterial appearance in 26% of 43 patients (46.2% of total) who demonstrated no bacteria before this trial. Among theses patients, almost all showed normal flora, but resistant bacteria and non-normal flora were found in 7% each.
In conclusion, local use of antibacterial agents for paranasal sinusitis has been thought to be more important as well as more effective than systemic treatment as a conservative therapy and the nebulization therapy is widely utilized because of its advantages as a painless therapy and its ability to spread an agent to plural paranasal sinuses simultaneously. However, we should avoid using nasal nebulization therapy unnecessarily over a long-term period because there is a chance of MIC increasing and superinfection with resistant bacteria and fungi.View full abstractDownload PDF (795K) -
Shitau Hirata, Takaharu Tatsukawa, [in Japanese], Koji Yajin, [in Japa ...1997 Volume 40 Issue Supplement3 Pages 195-200
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSAerozol therapy is one of the most popular and conservative therapies for the upper respiratory infectious disease. A little attention, however, has been paid for its side-effects against medical staffs and indoor air pollution in the treatment room.
In this paper, these side-effects were discussed by measuring the concentration of the medical particles using in nebulizer in the indoor air and the blood of medical staffs. The results are as follows ; 1) the medicine concentration in blood of medical staffs were below detectable level. 2) In a closed room, the medicine concentration at the same level of nebulizer apparatus was ten times more than at 50 cm high from the nebulizer apparatus. These detected concentration decreased by 20% by using a ventilator. 3) In the treatment room, the medicine was detected 7 m apart from the nebulizer apparatus on the condition that the ventilator was not working.
In conclusion, the authors emphasize that the ventilator is necessary for nebulizer therapy, and plural and stronger ventilators are more effective for the indoor air pollution by nebulizer particles.View full abstractDownload PDF (1128K) -
Shoji Matsune, Shigeru Furuta, Masaru Ohyama, Tsuyoshi Sato, Takenori ...1997 Volume 40 Issue Supplement3 Pages 201-205
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSAccording to our experimental study, it is obvious that an antibiotic solution is very effective in the treatment of sinusitis if it can be introduced in the paranasal sinuses constantly by a nebulizer. In this study using a jet nebulizer and RI (99mTc) counting technique for assessment, it was confirmed that the effort to make the middle meatus open by ENT specialists is quite important. In sinusitis cases with nasal polyps, polyps should be removed surgically in advance. In complicated sinusitis cases with nasal allergy, hyperthermia was effective as a preparatory step before jet nebulizer therapy. Catecholamines spray and/or gauze applied in the middle meatus can be a possible treatment for effective nebulizer therapy. After these treatments, swallowing duringnebulization increased the total count of RI introduced in the maxillary sinuses. While nebulizer therapy is quite easy in the out patient clinic, its indication to, and pretreatment of the middle meatus must be accurately assessed in each case for effective treatment of sinusitis.View full abstractDownload PDF (1592K) -
Shin-ichi Haruna, Masashi Ozawa, Yasue Haruna, [in Japanese], [in Japa ...1997 Volume 40 Issue Supplement3 Pages 206-211
Published: August 15, 1997
Released on J-STAGE: March 18, 2011
JOURNAL FREE ACCESSNebulizer therapy consisting of administration of a macrolide antibiotic (erythromycin) and other drugs was tested for its efficacy as treatment after endoscopic sinus surgery. When erythromycin was administered using a nebulizer, erythromycin was not detected from blood at all, while its concentration in the mucosa of paranasal sinuses was sufficient. The efficacy in improving diseased mucosa of paranasal sinuses was compared during a period from 3 months through 6 months after operation between a group treated with erythromycin nebulizer alone (nebulizer group ; 16 cases ; 32 diseased sides) and a group given an oral macrolide antibiotic alone in a small dose for a long period of time (RMX oral administration group ; 16 cases ; 32 diseased sides). In both groups, improvements in the endoscopic findings of the sinus and subjective symptoms were equal. Histologically, as well, good improvement in respiratory epithelium was observed in the nebulizer group. Observation of microbial flora during treatment with erythromycin nebulizer for a long period of time indicated that microbial substitution may occur. In conclusion, it is considered that erythromycin nebulizer therapy is useful as local treatment after endonasal operation.View full abstractDownload PDF (1868K)
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