Abstract
We report 3 cases of extremely rare, delayed, drug-induced eruption caused by Solu-Medrol ® (methylprednisolone sodium succinate) to treat acute peripheral neuropathy. One developed into extremely serious erythroderma requiring systemic management. We studied other corticosteroid preparations possibly causing allergic reactions and considered antigenicity based on chemical structure. We assumed the first case was one in which the prednisolone skeleton acted as an antigen regardless of the methyl and succinate groups.
