Chronic sinusitis may coexist with nasal allergy, and chronic sinusitis prognosis is affected by the pressence of nasal allergy.
To determaine differences in chronic sinusitis with and without nasal allergy, we measured interleukin-1β (IL-1β), IL-8, tumor necrosis factor-α (TNF-α), IL-4, IL-5, and leukotriene C4/D4/E4 in the paranasal sinus effusion taken by the YAMIK sinus catheter by enzyme-linked immunosorbent assay (ELISA).
Subjects were 6 patients with chronic sinusitis with nasal allergy, 8 patients with chronic sinusitis without nasal allergy, and 6 healthy subjects.
IL-1β, IL-8, and TNF-α were significantly higher in chronic sinusitis patients than in healthy subjects.No significant difference was seen in IL-1β, IL-8, and TNF-α between the patients of chronic sinusitis with nasal allergy and those without nasal allergy.
IL-5 and leukotriene C 4/D 4/E 4 were significantly higher in patients with chronic sinusitis with nasal allergy than in those with chronic sinusitis without nasal allergy and healthy subjects.
These results indicate that the degree of infectious inflammatiton in chronic sinusitis with nasal allergy and in chronic sinusitis without nasal allergy is severe and that eosinophilic inflammation occurs in sinus membrane of chronic sinusitis patients with nasal allergy.
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