Abstract
The infecting organisms responsible for pediatric acute otitis media were examined using bacterial culture inspections and drug susceptibility tests. Furthermore, the curative effect of CDTR-PI was examined. From July 2000 to March 2005, 41 children with acute otitis media consulted the Jikei Hospital's Department of Otorhinolaryngology. Twenty strains of Streptococcus pneumoniae (S. pneumoniae) (24.7 %), 20strains of Haemophilus influenzae (H. influenzae) (24.7 %) and 10 strains of Moraxella catarrhalis (M. catarrhalis) (12.3 %) were isolated from among the 81 strains isolated from the 41 children. In 35 of the 41 children (85.4 %), these three major infecting organisms were involved. The detection rate of drug-resistant bacteria among these three major infecting organisms was mostly in agreement with the results of previous reports. Based on the results of the drug susceptibility tests, CDTR was the most useful antibiotic against S. pneumoniae and H. influenzae. Clinically, the symptoms of the pediatric acute otitis media patients improved after treatment with CDTR-PI. Therefore, CDTR-PI appears to be a very useful oral antibiotic for the treatment of pediatric acute otitis media. However, antibiotics must be used cautious to minimize the appearance of drug-resistant bacteria.
