ゲンタマイシン灌流による膜蝸牛ポリフォスフォイノシタイド代謝の抑制

抄録

The perilymphatic perfusion of gentamicin C_la (10^-2M) supressed cochlear microphonics by 62% within 30 min and decreased tne ³²P-incorpo-ration into phosphatidilinositol diphosphate in the organ of Corti while that of the lateral wall of the cochlear duct remained unchanged. Ratios of the ³H-glycerol incorporation into neutral lipids and phospholipids were not affected by gentamicin in either of the tissues. The ultrastructure of the perfused cochlea was essentially normal except for occasional ntracellular precipitation line in the hair cells. these data together with other data strongly suggest that the inhibition of the polyphosphoinositides metabolism was the early and primary action of the aminoglycoside antibiotics in the cochlea.