分裂阻害剤の蝸牛内神経毒性

神経微小管の変化について

抄録

Perfusions of the perilymphatic space were done with dilute concentrations of vincristine and colchicine. Electron microscopy of the intra-cochlear elements revealed only changes of the microtubules in the neural elements. Formation of the vincristine-induced paracrystal and reduction in number of microtubules by colchicine were observed both in the myelinated and the unmyelinated nerve fibres. These antimitotic agents did not affect the microtubules in the other elements of the cochlear. The posibility of the neural hearing loss induced by the anti-mitotic agents was offered.