Abstract
The medical decompression of endolymphatic hydrops is the chief therapy of Meniere's disease. Especially, Isosorbide, one of the osmotic diuretics, is clinicaly confirmed to be effective for Meniere's disease. In order to establish the ground of the medical decompression of endolymphatic hydrops, Isosorbide was administered to the guinea pigs with experimental endolymphatic hydrops. Endolymphatic hydrops was readily produced experimentaly by cauterizing the endolymphatic sac with 10% silver nitrate solution.
The following results were obtained, 1) The cochlear structures were observed after administering Isosorbide and foldings in Reissner's membrane were commonly seen.
2) The hearing loss of guinea pigs with hydrops were not remarkably improved by intravenous injection of Isosorbide.
3) Administration of Isosorbide reduced endolymphatic pressure of guinea pigs with hydrops.
4) The osmotic pressure of serum and perilymphatic fluid of normal guinea pigs ascended after administering Isosorbide.
