抄録
Collagenase activity was investigated in cholesteatoma epithelium, temporal bone and ear canal skin. The enzyme extracted from tissues was proven to be collage nase by disc electrophoresis. Cholesteatomas displayed different two types; where activity in cholesteatoma was higher than that in bone, conversely where activity in bone was higher than that in cholesteatoma. These findings suggest that collagenase is synthesized in cholesteatoma epithelium, resulting in collagen degradation and bone destruction, and that some variation of collagenase activity in cholesteatoma may be due to the type of cholesteatoma, active or inactive.
