モルモット血管条及びラセン靱帯の毛細血管の透過性に関する微細構造的観察補遺
1982 年 13 巻 1 号 p. 39-42
詳細
1982 年 13 巻 1 号 p. 39-42
It is generally believed that the stria vascularis capillary is permeable to intravascularlly administered horseradish peroxidase (HRP) by active vesicular transport. In the present study, in order to examine the existence of some direct pathway across the endothelium, HRP was intravascularlly injected concominant with the fixative after 30 minutes' perfusion fixation in the guinea pig. Leakage spots of HRP from capillaries were sparsely located all over the stria vascularis. In the leaky segment the endothelial basement menbrane was densely stained with the traser. In the endothelium of this segment there were regions in which many labeled micropinocytotic vesicles were gathered, which suggested formation of transendothelial channel. And, moreover, a single isolated endothelial fenestra was sometimes observed in the leaky segment. These results indicate that there exists a passive direct pathway in the stria vascularis capillary. It is concluded that the transendothelial channel and the single isolated fenestra contribute to the high permeability of the stria vascularis capillary, in addition to the active vesicular transport which is generally accepted.
