内耳液静水圧の変動
浸透圧利尿剤の影響を中心として
1986 年 17 巻 1 号 p. 25-28
詳細
1986 年 17 巻 1 号 p. 25-28
Hydrostatic pressure of the endo- and perilymph in the guinea pig cochlea was studied with a servo-controlled micropipet system. Both endo- and perilymphatic pressure increased in a linear manner without any time lag or dampening as the CSF was pressurized over a range of 0 to 50mmHg. Following the instillation of saturated NaCl solution (0.1ml) into the middle ear, labyrinthine pressure measurement showed gradual declines in endolymph and perilymph with a minimum pressure at 15 to 20min and slow recovery during the next 20 min. Systemic administrations of osmotic agents (glycerol, urea and mannitol) produced a substantial pressure reduction in both endo- and perilymph with a maximum reduction at 20 to 30 min. Difference in pattern of the pressure changes between the labyrinthine fluids and CSF indicastes a possible dehydration effect in the inner ear for glycerol and urea, but and ambiguous effect for mannitol.
