内耳におけるアナフィラトキシン活性について (第2報)

抄録

Effects of anaphylatoxins on the stria vascularis of guinea pigs were studied by light-microscopy and electron-microscopy by the tracer method of horseradish peroxidase (HRP). We made anaphylatoxins from guinea pig serum plus zymosan. Anaphylatoxins were inoculated into the carotic artery. After 10 minutes, the stria vascularis were found morphologically normal by light-microscopy and electron-microscopy. After 24 hours, the stria vascularis were not atrophied but showed cystic formation. Leakage of HRP from capillaries was observed by electron-microscopy in the stria vascularis in cochlear fourth turn. After 48 hours, cystic formation in the stria vascularis was enlarged, and Reissner's membranes were collapsed in other guinea pigs. After 72 hours, the stria vascularis in the various cochlear turns, except cochlear basal turn, were extremely atrophied. These results suggested that anaphylatoxins were closely related with the inner ear disease.