Abstract
It was proved by the toluidine blue method in vitro that heparin and chondroitin sulfate had strong binding ability to aminoglycoside. Reduction of Kanamycin ototoxicity was slightly observed by a simultaneous application of heparin to guinea pigs through electrocochleography and morphological investigation with SDH staining. But the protective effect of gentamicin ototoxicity by chondroitin sulfate was not detected. In order to protect cisplatin (CDDP) ototoxicity, sodium thiosulfate (STS) was used. When STS was administrated early after CDDP injection to the guinea pigs, remarkably reduced CDDP ototoxicity was noted by means of scanning electron microscopy. However, when an application of STS was late, protective effect was not strong. Furthermore, there was a mild protection effect by infusion of STS into the middle ear cavity.
