Abstract
The protective effect of fosfomycin against ototoxicity induced by aminoglycoside antibiotic and cisplatin and its analog carboplatin was investigated in Fisher rats. Drug-induced toxic side effects of ototoxicity and nephrotoxicity, or myelo-suppression effect due to carboplatin were reduced functionally or histopathologically by the coadministration with fosfomycin. No influence of fosfomycin against the antitumor effect of cisplatin was clarified using ddy-strain mice inoculated with Ehrlich carcinoma cells. Clinically, nephrotoxicity was lower after the combined administration of cisplatin and fosfomycin than after cisplatin alone. The combined administration of fosfomycin and ototoxic drugs has significantly lower toxicities and greater therapeutic efficacy.
