抄録
Authors showed the inhibitory effect of Cepharanthin, a kind of Alkaloid, on the teratogenicity of maternal hypervitaminosis A in the rat in the previous reports. In the present study, the similar inhibitory effect of Cepharanthin was confirmed in the mouse too. The ddN mother mice were injected intraperitoneally excessive Vitamin A on the 8th day of pregnancy and some of them were injected simultaneously Cepharanthin in the same way. The mouse fetuses from mothers treated with excessive Vitamin A showed external abnormality much more than fetuses from mothers treated with Vitamin A and Cepharanthin. Besides, internal malformations in the ear region observed by means of bone and cartilage staining showed inhibitory effect of Cepharanthin on teratogenicity of excessive Vitamin A as like in the rat.
