Abstract
Drug pathways to Corti's organ of guinea pig was investigated under normal and experimental conditions by morphological technique. Under normal condition systemically injected small molecular weight substance which are kanamycin (KM) and lanthanum ion (LA) can get to Corti's organ from early time via capillaries of tympanic lip and basilar membrane. As time goes on (1.5 hs. after administration), KM which comes from perilymphatic space accumulates to Corti's organ.
On the other hand, pre-administered KM very easily can get to Corti's organ from early time via capillary and perilymphatic pathways when furosemide (FM) is added. This alteration aspect of BLB might lead to inner ear damage and inner ear therapy by using drug.
