フロセマイドとウワバインの中央階K⁺活量に及ぼす影響の比較

抄録

Endocochlear potential (EP) and K⁺ activity in the scala media were recorded by means of K⁺ sensitive doublebarrelled microelectrodes in the second turn of the cochlea of the guinea pig during the perilymphatic perfusion of furosemide and ouabain. Furosemide produced a less decrease in K⁺ activity relative to the EP decrease than ouabain. The result suggests that furosemide reduces the EP by different mechanisms from the deterioration of K⁺ secretion potentig resulting from the inhibition of Na⁺-K⁺ ATPase.