ヒト中耳滲出液のプロスタグランディンについて

抄録

The etiology of otitis media with effusion (OME) has not been conclusively established. The biochemical characteristics of middle ear effusion (MEE) indicate inflammatory state. Although prostaglandins (PGs) have been detected in MEE, the exact measurement of PGs has not been made. In this study, concentrations of PGs were measured by radioimmunoassay (RIA) in human MEE. Each sample of MEE from OME was devided into two groups, which were serous effusions and mucoid ones. The main PG in both serous and mucoid effusions was TXB₂, followed by PGE₂. PGD₂, PGF_2α, and 6ketoPGF_1α were also found in MEE with a smaller quantity. The amounts of each PGs in mucoid effusions were two or three times higher than those in serous effusions. But protein concentration is almost the same between mucoid and serous group. These results suggest that PGs may play important roles as a mediator of the inflammatory response in the pathogenesis of MEE.