Lymphatic vessels were few in the edematous perimatrix of cholesteatoma which contained mucus-like substance in the intercellular space. The lymphatic vessels contained same mucus-like substance and their endothelial cells were degenerated. In the fibrous perimatrix, abundant fibroblasts, regenerating blood vessels and nomal lymphatic vessels were observed. Macrophages infiltrated and phagocyted cell debrises. Degeneration and regeneration were together present in the perimatrix. It was suggested that confined mucous epithelium behind the matrix might cause the degeneration of perimatrix.