1989 年 20 巻 1 号 p. 149-150
The relation between the number of incidents of inflammation and pneumatization was investigated in pigs, whose tympanic bullae closely resemble the human mastoid air cell system. Otitis media was induced by injecting glycerin into the middle ear cleft, with injections given once, twice, three times, or four times 4 to 7 weeks after birth. All of the bullae were removed at six months after birth to compare them and determine the degree of pneumatization.
As the number of injections increased, the development of the air cell system was inhibited more severely owing to the impairment of osteoclastic activity by osteoclasts. It was concluded that the number of incidents of inflammation is an important factor affecting the degree of pneumatization.