中耳腔におけるSurfactant様物質 その4
1989 年 20 巻 1 号 p. 171-172
詳細
1989 年 20 巻 1 号 p. 171-172
Monoclonal antibodies (PC-6, PE-10) against pulmonary surfactant apoprotein (SP) were developed and were used to measure SP in middle ear effusions (MEE) by using simultaneous two monoclonal antibodies immunoassay. Thirty-nine percent (39/100) of MEE showed positive for SP and the duration of illness in the SP-positive cases (15.2 months) were significantly shorter than those in the SP-negative cases (24.5 months). There was a trend that frequencies of myringotomy and tube insertion were decreased in the SP-positive cases. Such studies have potential implication regarding the existence of SP in the middle ear cavity and the possible role of SP in the pathogenesis of otitis media with effusion.
