培養真珠腫組織の産生する骨吸収活性 (第2報)
1989 年 20 巻 1 号 p. 189-190
詳細
1989 年 20 巻 1 号 p. 189-190
The cholesteatoma tissue and the granulation tissue of simple chronic otitis media produced intense bone resorbing activity and a large amount of prostaglandin (PG) E2. Under the influence of indomethacin, however, relatively intense activity of bone resorption was found only in cholesteatoma, whereas PGE2, production was suppressed completely. Such activity produced by cholesteatoma was blocked by the anti-interleukin (IL) -1α antibody. Significant levels of IL-1α were detected only in cholesteatoma culture supernatants. It is suggested, therefore, that the bone destruction in cholesteatoma may be attributable to IL-1α rather than to PGE2.
