サリチル酸の蝸牛外リンパへの移行

抄録

We have reported the concentrations of furosemide (FU) and penicillin G (PG) in the scala tympani (ST) and in the scala vestibuli (SV) of the guinea pig cochleae to clarify the transportaion mechanism of organic anions from plasma to perilymph. In this study, the concentrations of salicylate (SA) and aspirin (ASA) in sequential samples from ST and SV perilymph of the guinea pig after intravenous injection of 100mg/kg SA or ASA were measured by high-performance liquid chromatography. The SA kinetics in the ST perilymph are very similar to those in the SV perilymph. These results are not analogous to our FU or PG experiments suggesting the pronounced difference of anion transportation mechanism between the ST and the SV. The different transport mechanism between SA and FU is suggested in the ST of the guinea pig.