Using guinea pigs, systemic blood pressure, cochlear blood flow and perilymphatic Po2 were recorded simultaneously, during Glycerol infusion. To make comparison between Glycerol and Furosemide, same experiment was performed on Furosemide. By intravenous injection of 40% Glycerol (2ml/kg), cochlear blood flow increased more rapidly than systemic blood pressure and perilymphatic Po2.
After the administration of Furosemide (10mg/kg), a slow decrease of systemic blood pressure occurred with paralleled changes of cochlear blood flow and perilymphatic Po2. These decrease o f cochlear blood flow and perilymphatic Po2 were considered to be dependent on the systemic blood pressure changes, indicating the evident difference between Glycerol and Furosemide in the effect on cochlear blood flow and perilymphatic Po2.
