頭蓋内圧上昇が蝸牛血流に及ぼす影響

抄録

Laser doppler flowmetry was used to study the effect of increased intracranial pressure on cochlear blood flow (CBF) in guinea pigs. Endocochlear potential (EP) and endolymphatic pressure were measured simultaneously with a servo-controlled micropipet system. Endolymphatic pressure increased with little or no time lag as the intracranial pressure rose. When the intracranial pressure rose above a critical point, the CBF decreased suddenly and a little later EP started going down gradually. These changes were completely reversible upon release of intracranial pressure. We conclude that increased intracranial pressure causes an impediment in the circulation of cochlea.