We had reported the change of endocochlear dc potential (EP) on normal guinea pigs which were breathed 5%O2+95%N2 gas or 2.5%O2+97.5%N2 gas. The EP decreased rapidly and then increased Slowly. The time course of the EP is dependent on the functions of stria vascularis and hair cells. In this report, we studied the change of EP on the kanamycin sulfate (KM) administrated guinea pigs which were breathed 5%O2+95%N2 gas or 2.5%O2+97.5%N2 gas. On the KM administrated guinea pigs, the EP also decreased rapidly and then increased slowly. The reaction of that was later than that of normal. The reduction of EP of that was smaller than that of normal. It is suggested that stria vascularis have the function stabilized EP in 80-90mV.
