外傷性内耳瘻の研究

抄録

Operator is usually forced to remove inflammatory tissues near or around the stapes in middle ear surgery. We often experienced post operative sensorineural hearing loss in spite of much care of operative procedure. To study influences of inner ear due to eperative procedure, experimental different three conditions were made using guinea pigs. These are pushing stapes into cochlea directly with a needle, making a small perforation to the scala tympani of the cochlea by small burr and stapes mobilization. The first two conditions occur perilymph fistula and last one occurs the pressure change in perilymph indirectly. The conditioned guinea pigs were sacrificed just after the operation, 7 days later and 1 month later, and then cochlea were removed. Under light and scanning microscope, organ of corti was examined. Damage were observed mainly in outer hair cells of 2nd or 3rd turn.