Serial section of 20 temporal bones taken from 10 patients with leukemia were studied histopathologically. Inspite of showing pathological findings due to leukemia in all cases, the otological symptoms such as vertigo, facial palsy, sudden deafness, and mass formation of external auditory canal were manifested in only 4 cases. Hemorrhagic changes found particularly in internal auditory meatus of 18 ears, middle ear of 12 ears, and external auditory canal of 8 ears. Leukemic infiltration was observed in internal auditoty meatus of 12 ears, middle ear of 11 ears, and external auditory canal of 6 ears. It was noted that otological symptoms of various types were caused by hemorrhage and or leukemic infiltration into the temporal bone and leukemic pathological change could happen in any site of the temporal bone.