呼吸停止負荷による内リンパ嚢DC電位の変化に対するβ-blockerの影響

抄録

The effect of asphyxia on the endolymphatic sac DC potential (ESP) was examined in the guinea pig. Asphyxia was administered for 1.5 min by stopping the respirator. The ESP decreased in amplitude during asphyxia. After the termination of asphyxia the ESP showed a diphasic recovery pattern. When the respiration was resumed, the ESP decreased again following a transient recovery. Thereafter the ESP showed a gradual recovery. β-blocker (propranolol) inhibited a decrease in the ESP after the resumption of respiration, but not a α-blocker (phentolamine).The result indicates that the ESP decrease after the resumption of respiration is induced by-βadrenergic action.