抄録
Cisplatin (CDDP) is known to have toxic effects on inner ears. There are numerous reports about hearing disturbances and damage of the cochleas, but there are very few about vestibular disturbances. We discuss this problem in the following SEM study. Guinea pigs were injected peritoneally with 5 mg/kg or 10 mg/kg CDDP. Pathological changes were observed right after CDDP administration. Exfoliation of cilia was eminent at the central part of the ampullae, while II type cells at both ends of the ampullae were rather well preserved. Cilia in the utricles were deranged but not exfoliated. The structure of the saccules were almost normal without derangement or exfoliation of cilia.
