真珠腫組織内におけるコレステロール代謝についての研究

抄録

At the present time, the origin of the cholesterol in the cholesteatoma is still uncertain. In this study, we cultured the tissues of cholesteatoma and added ¹⁴C-acetic acid and ³H-leucine to measure the synthesis of cholesterol in cholesteatoma in vitro. Acetic acid and leucine are one of the precursors of cholesterol synthesis. This result showed that the cholesterol derived from acetate did not exist in cholesteatoma tissue. On the other hand, the cholesterol derived from leucine exists in cholesteatoma. This result suggests that the cholesterol in cholesteatoma is synthesized in the tissue in vivo.