Chinese Herbal Medicine TJ-10（SAIKO-KEISHI-TO） attenuated the reducton of NK cell activity in chronic pain model rats

Abstract

   Saiko-keishi-to (TJ-10), Chinese Herbal medicine extract, is effective for trigeminal neuralgia clinically, but the mechanism is not yet clear. We made the chronic pain model by ligation of trigeminal tertiary branch (mental nerve) in rats and examined the effect of analgesia and about immunocompetence. In preliminary research, it is shown that pain threshold and immunocompetence decreased in this chronic pain model. In the present study, both decrease of the pain threshold in the ligation side and decrease of immunocompetence were restrained in TJ-10 treated group. In tail flick test, pain threshold by TJ-10 administration was not changed. And the TJ-10 administration did not give a change to immunocompetence with an intact rat. As a result, a small regional pain of territory of mental nerve brings large influence in biogenic immunoreactivity, but this suggests possibility competed in TJ-10.