This study describes an original view of the expected process intensification (PI) and a methodology for its realization by comparing the history and trends of PI in the world with those in Japan. It is presently thought that PI should be a model-based process design strategy involving technological innovation at the core of green process engineering (GPE) with the aim of a functional quantum leap. From another viewpoint, PI seems to have its rise in aiming at inherently safer processes. Inherently safer process design means a design concept considering inherent safety at the first step of process design. As approaches to inherently safer process design, the strategy of "minimize" is the most important, and it is rephrased as "intensification." Recent trends of PI seem to be systematic integration using innovative process equipments, alternative energy sources, and new process operations from the viewpoints of three categories, which are the on-site system, the utility system and the operation system. There are many concrete candidates of PI technologies, and above all, compact reactors, ultrasonic and periodic operation are especially interesting for us. An example of our research is compact polymerization intensified by unsteady ultrasonic operation. The synergy effect of systematic integration with a compact reactor and unsteady ultrasonic operation is expected.