Unsteady ultrasonic irradiation and temperature control are thought to be effective in control of particles in suspension polymerization process. By ultrasonic irradiation in polymerization, particles with large diameter and with a little adhesion of minute particles are observed. In the present study, we propose a feedback operation system where polymerization section and ultrasonic irradiation section are separated. By irradiating ultrasound to a part of reaction solution in the feedback operation, effects of unsteady ultrasonic irradiation on characteristics of generated particles are investigated. As an analytical result for generated particles by scanning electron microscope, the above-mentioned effects of ultrasonic irradiation are also observed in the polymerization with feedback operation. Moreover, the volume of solution under ultrasonic irradiation and the timing of feedback operation are seen to be important operating variables for controlling particle size distributions.