The current study was undertaken to evaluate the effect of sanazole as a sonosensitizer at previously studied acoustic conditions of different pulse repetition frequencies using two cell lines representatives of solid tumors and hematopoietic cancers. Sanazole alone displayed selective cytotoxic effects towards solid tumor-derived cancer cells resulting in complete cell death after 24 hr treatment and enhanced the ultrasound-induced cell killing after 6 hr post-treatment. The enhancement seemed to be mediated by an additive increase in intracellular oxidative stress levels. Sanazole seems to be an efficient cytotoxic agent for the treatment of solid tumors and a promising sonosensitizer under aerobic conditions.
