P16 セルロースから調整されたハイドロゲルからの超音波によるニコチン放出に関する研究

抄録

Efficient and control release of Nicotine is essential in treatments for neurodegenerative diseases. So, 0.1 wt% of Nicotine loaded biocompatible cellulose hydrogels were prepared using phase-inversion method and exposed to ultrasounds (US) at different US powers (10W and 30W), and frequencies (23 kHz, 43 kHz and 96 kHz). Then, released Nicotine concentrations were studied using UV-Vis spectra to observe the effectiveness of US on Nicotine release. US frequency of 43 kHz at 30 W shows the highest Nicotine release from the hydrogels prepared from solution contains 0.1 wt% Nicotine and 0.9 wt % of cellulose.