A10 バイオマスヒドロゲルからの薬剤放出促進に関する超音波と機械刺激の効果

抄録

As compared with other stimuli such as light and heat, the advantages of US are non-invasiveness and non-ionizing radiation. For drug release applications, drug release control by weak power US is preferable. In the present study, by using nicotine loaded cellulose hydrogels, effect of the US and mechanical strain was investigated on the loaded nicotine for releasing with the triggers. Nicotine loaded cellulose hydrogel was prepared from cotton using phase-inversion process. Then, outernal US or mechanical strain trigger was exposed. The release nicotine efficiencies in the US system were higher than that of the no US system. When 1% strain was exposed during the US operation, the US stimulus effect on the nicotine release was highly enhanced. For example the released nicotine concentration increased to 19 μg /mL when 90 min was operated, indicating twice relative to only US irradiation. This indicated that the combination of US and mechanical strain could well broke the cellulose hydrogel matrix.